- Free worldwide shipping, tracked and insured
- Same day dispatch, customs handled
- Certificate of analysis for every batch
- Neuronal-culture and neuroprotection research
- Reactive-oxygen-species and cell-viability studies
- Cognitive-aging and learning models
Overview
What is Pinealon?
Pinealon is a synthetic tripeptide, Glu-Asp-Arg (EDR), from the Khavinson series of short peptide bioregulators. It is used as a research compound in studies of neuronal cell viability, reactive-oxygen-species accumulation, and cognitive-aging models. Supplied for in-vitro and laboratory research use only.
Research applications
Where Pinealon is used in research
Areas of study described in the published literature. Listed for research reference only.
Neuroprotection models
Used in research on ROS accumulation and cell viability in neuronal and PC12 cultures.
Cognitive aging
Studied in rodent models for spatial learning and neuronal oxidative markers.
Neurodegeneration research
Explored in neuronal cultures modelling Alzheimer and Huntington pathology.
Signalling pathways
Applied to investigate MAPK/ERK, caspase-3, and antioxidant-enzyme expression.
Mechanism in research
How Pinealon is studied
In published research, Pinealon was reported to limit reactive-oxygen-species accumulation and necrotic cell death in cerebellar granule cells, neutrophils, and PC12 cells under oxidative stress, with delayed ERK1/2 activation and cell-cycle modulation, leading the authors to propose direct interaction with the genome. A rat prenatal hyperhomocysteinemia model reported improved offspring spatial learning and reduced neuronal ROS, and a review proposed entry into cells and binding to histones or RNA, with downstream effects on MAPK/ERK, caspase-3, p53, SOD2, and GPX1. These findings come from cell and animal models; corresponding mechanisms in humans are not established.
Reported targets & pathways
- Reactive oxygen species (ROS) accumulation
- MAPK/ERK1/2 signalling
- Caspase-3 and p53 apoptosis pathway
- SOD2 and GPX1 antioxidant enzymes
Reference data
Pinealon specifications
- Sequence
- Glu-Asp-Arg (EDR)
- Classification
- Synthetic brain tripeptide bioregulator
- Appearance
- White lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Molecular formula
- C15H26N6O8
- Molecular weight
- 418.4 g/mol
- Purity
- 99.55%
- CAS number
- 175175-23-2
- PubChem CID
- 10273502
Selected research
Published studies on Pinealon
Peer-reviewed references for further reading. Findings describe in-vitro and animal research; mechanisms and outcomes in humans are not established.
Rejuvenation Research · 2011
Reported that Pinealon dose-dependently limited ROS accumulation and necrotic death in cerebellar granule cells, neutrophils, and PC12 cells under oxidative stress, with delayed ERK1/2 activation.
International Journal of Clinical and Experimental Medicine · 2012
Reported that Pinealon given to methionine-loaded pregnant rats improved offspring spatial orientation and learning and reduced ROS and necrosis in offspring cerebellar neurons.
Molecules · 2020
Reviewed reports that EDR reduces neuronal apoptosis and preserves dendritic spines in neurodegeneration cultures, and proposed histone and RNA binding affecting MAPK/ERK, caspase-3, p53, SOD2, and GPX1.
Quality
Independently verified, batch by batch
Tested every batch
Every batch of Pinealon is independently analyzed by a third-party laboratory before it is released.
Independently verified
Identity and purity are confirmed by an independent third-party laboratory. This batch is verified to 99.55% purity.
Certificate of analysis
Every batch is independently tested with a certificate of analysis. A digital COA is available on request.
Reviews
What researchers say about Pinealon
long haul down under
Ordered pinealon after the huberman episode mentioned it, mostly because two of our PhD students wouldnt stop asking. Product side is fine, cultures happy enough. The transit was the issue, 16 days to brisbane with a week stuck at a sorting hub somewhere in between, and the tracking page didnt update for most of it. If you are in australia order well ahead.
un pò scettica all'inizio
Non conoscevo il pinealon prima che un collega me ne parlasse e ammetto che ero un pò scettica, un tripeptide così corto. Arrivato a Bologna in una settimana, flaconi interi. Nelle colture neuronali i valori si sono mossi come descritto in letteratura, quindi mi ricredo, almeno per ora.
finance was not thrilled
Murcia lab here. First box of pinealon went so well we ordered again before it was finished, which the finance person was not thrilled about. Cognitive-aging model, two lots, same readout in our hands.
four days flat
pinealon to haarlem in four days, vials fine, into the cultures monday
läuft in den kulturen
pinealon für unsere neuronalen kulturen, hatten wir vorher noch nie. hamburg in sechs tagen, nichts geplatzt. wir haben erst gedacht dass so ein kurzes tripeptid nicht sauber lyophilisiert aber die kuchen sahen ordentlich aus und die messwerte in der kultur passen zu dem was publiziert ist
blame the podcast
yeah i ordered pinealon after the huberman episode name dropped it, not proud of it lol. york in 5 days. went into the neuronal cultures the week after and the viability counts didnt do anything weird. supervisor doesnt know it was a podcast purchase
Pinealon FAQ
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