- Free worldwide shipping, tracked and insured
- Same day dispatch, customs handled
- Certificate of analysis for every batch
- Anti-inflammatory pathway research
- Immune modulation studies
- Gut and intestinal inflammation research
Overview
What is KPV?
KPV is a tripeptide (Lys-Pro-Val), the C-terminal fragment of alpha-MSH, used as a research compound in studies of anti-inflammatory and immune-modulation pathways. Supplied for in-vitro and laboratory research use only.
Research applications
Where KPV is used in research
Areas of study described in the published literature. Listed for research reference only.
Intestinal inflammation
Used in research on inflammatory markers in cell and animal colitis models.
Immune modulation
Studied for anti-inflammatory activity as an alpha-MSH C-terminal fragment.
Transporter uptake
Applied to investigate PepT1-mediated uptake into epithelial and immune cells.
Melanocortin pharmacology
Explored alongside core melanocortin peptides to compare anti-inflammatory profiles.
Mechanism in research
How KPV is studied
In published research KPV was reported to be taken up into intestinal epithelial and immune cells via the PepT1 transporter, and in that setting to reduce markers of inflammation in cell and mouse colitis models. Additional research described an anti-inflammatory profile distinguishable from that of the core melanocortin peptides. These pathways are investigated in models of intestinal and immune inflammation; corresponding mechanisms in humans are not established.
Reported targets & pathways
- PepT1 peptide transporter
- NF-kB inflammatory signaling
- Melanocortin pathway (alpha-MSH fragment)
- Intestinal epithelial and immune cells
Reference data
KPV specifications
- Sequence
- Lys-Pro-Val (KPV)
- Classification
- Tripeptide, alpha-MSH C-terminal fragment
- Appearance
- White lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Molecular formula
- C16H30N4O4
- Molecular weight
- 342.43 g/mol
- Purity
- 99.41%
- CAS number
- 67727-97-3
- PubChem CID
- 125672
Selected research
Published studies on KPV
Peer-reviewed references for further reading. Findings describe in-vitro and animal research; mechanisms and outcomes in humans are not established.
Gastroenterology · 2008
Reported that KPV was taken up into intestinal epithelial and immune cells via the PepT1 transporter and, in that setting, reduced markers of inflammation in cell and mouse colitis models.
Journal of Pharmacology and Experimental Therapeutics · 2003
Observed that the C-terminal alpha-MSH tripeptide KPV exhibited an anti-inflammatory profile distinguishable from that of the core melanocortin peptides in the models examined.
Quality
Independently verified, batch by batch
Tested every batch
Every batch of KPV is independently analyzed by a third-party laboratory before it is released.
Independently verified
Identity and purity are confirmed by an independent third-party laboratory. This batch is verified to 99.41% purity.
Certificate of analysis
Every batch is independently tested with a certificate of analysis. A digital COA is available on request.
Reviews
What researchers say about KPV
first go with kpv
We mostly run the larger melanocortin peptides so figured wed try the fragment on its own for once. Came to ottawa in about a week and it reconstituted clear, too early to say much but nothing looks off so far
solid first order
first proper order of the fragment on its own, no complaints so far and it got to dublin without fuss
steady tripeptide
been our go to for the tripeptide, steady batch to batch and it just does the job on our inflammation panels
geld gut angelegt
kpv ist bei uns inzwischen gesetzt. löst sich sauber, bleibt über die ganze versuchsreihe stabil und der preis geht für das was man bekommt völlig klar. karton kam auch heil an
restocked
second kpv order, into rotterdam in about a week. sealed clean and working fine on our barrier assays
quiet reorder
third kpv order and honestly i stopped checking it as close as i used to, its just been the same good stuff every time. quick into oslo too
KPV FAQ
Shipping KPV to India?
Free shipping, UPI payments, INR pricing, and same-day dispatch.
Related Products
BPC-157
99.77% pureBody protection compound derived from human gastric juice, researched for tissue repair, gut health, and injury recovery.
TB-500
99.49% pureSynthetic analogue of Thymosin Beta-4, studied for tissue regeneration, wound healing, and inflammation modulation.
