- Free worldwide shipping, tracked and insured
- Same day dispatch, customs handled
- Certificate of analysis for every batch
- Anti-inflammatory pathway research
- Immune modulation studies
- Gut and intestinal inflammation research
Overview
What is KPV?
KPV is a tripeptide (Lys-Pro-Val), the C-terminal fragment of alpha-MSH, used as a research compound in studies of anti-inflammatory and immune-modulation pathways. Supplied for in-vitro and laboratory research use only.
Research applications
Where KPV is used in research
Areas of study described in the published literature. Listed for research reference only.
Intestinal inflammation
Used in research on inflammatory markers in cell and animal colitis models.
Immune modulation
Studied for anti-inflammatory activity as an alpha-MSH C-terminal fragment.
Transporter uptake
Applied to investigate PepT1-mediated uptake into epithelial and immune cells.
Melanocortin pharmacology
Explored alongside core melanocortin peptides to compare anti-inflammatory profiles.
Mechanism in research
How KPV is studied
In published research KPV was reported to be taken up into intestinal epithelial and immune cells via the PepT1 transporter, and in that setting to reduce markers of inflammation in cell and mouse colitis models. Additional research described an anti-inflammatory profile distinguishable from that of the core melanocortin peptides. These pathways are investigated in models of intestinal and immune inflammation; corresponding mechanisms in humans are not established.
Reported targets & pathways
- PepT1 peptide transporter
- NF-kB inflammatory signaling
- Melanocortin pathway (alpha-MSH fragment)
- Intestinal epithelial and immune cells
Reference data
KPV specifications
- Sequence
- Lys-Pro-Val (KPV)
- Classification
- Tripeptide, alpha-MSH C-terminal fragment
- Appearance
- White lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Molecular formula
- C16H30N4O4
- Molecular weight
- 342.43 g/mol
- Purity
- 99.41%
- CAS number
- 67727-97-3
- PubChem CID
- 125672
Selected research
Published studies on KPV
Peer-reviewed references for further reading. Findings describe in-vitro and animal research; mechanisms and outcomes in humans are not established.
Gastroenterology · 2008
Reported that KPV was taken up into intestinal epithelial and immune cells via the PepT1 transporter and, in that setting, reduced markers of inflammation in cell and mouse colitis models.
Journal of Pharmacology and Experimental Therapeutics · 2003
Observed that the C-terminal alpha-MSH tripeptide KPV exhibited an anti-inflammatory profile distinguishable from that of the core melanocortin peptides in the models examined.
Quality
Independently verified, batch by batch
Tested every batch
Every batch of KPV is independently analyzed by a third-party laboratory before it is released.
Independently verified
Identity and purity are confirmed by an independent third-party laboratory. This batch is verified to 99.41% purity.
Certificate of analysis
Every batch is independently tested with a certificate of analysis. A digital COA is available on request.
Reviews
What researchers say about KPV
nochmal kpv bestellt
Zweite Lieferung nach München. In sechs Tagen da, Verpackung tadellos. Für unsere Modell Arbeit passt KPV gut, weil wir damit stabile Ausgangswerte hinbekommen
read the committee coverage first
been watching the kpv advisory panel coverage since july, ordered a first lot after. came through to sligo no problem and the barrier assay numbers are sitting around what's published.
kpv in the rotation
had been using kpv through the klow blend for a while, figured it was time to try it on its own. panels came back right where theyd been before. packaging was fine, nothing rattled loose
thought they shorted us
Barely anything in the glass when you hold it up, first lot I was half ready to email them. Mass was right on the balance. Eight days to Liège.
inga flagor
Löste sig fint, inga flagor eller nåt. Leverans tiden till Uppsala var en dryg vecka
half what we were paying
came off a us supplier that wanted nearly double for the same thing so we tried this instead and the kpv has been fine on the barrier side, about six days into athens
KPV FAQ
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