- Free worldwide shipping, tracked and insured
- Same day dispatch, customs handled
- Certificate of analysis for every batch
- Anti-inflammatory pathway research
- Immune modulation studies
- Gut and intestinal inflammation research
Overview
What is KPV?
KPV is a tripeptide (Lys-Pro-Val), the C-terminal fragment of alpha-MSH, used as a research compound in studies of anti-inflammatory and immune-modulation pathways. Supplied for in-vitro and laboratory research use only.
Research applications
Where KPV is used in research
Areas of study described in the published literature. Listed for research reference only.
Intestinal inflammation
Used in research on inflammatory markers in cell and animal colitis models.
Immune modulation
Studied for anti-inflammatory activity as an alpha-MSH C-terminal fragment.
Transporter uptake
Applied to investigate PepT1-mediated uptake into epithelial and immune cells.
Melanocortin pharmacology
Explored alongside core melanocortin peptides to compare anti-inflammatory profiles.
Mechanism in research
How KPV is studied
In published research KPV was reported to be taken up into intestinal epithelial and immune cells via the PepT1 transporter, and in that setting to reduce markers of inflammation in cell and mouse colitis models. Additional research described an anti-inflammatory profile distinguishable from that of the core melanocortin peptides. These pathways are investigated in models of intestinal and immune inflammation; corresponding mechanisms in humans are not established.
Reported targets & pathways
- PepT1 peptide transporter
- NF-kB inflammatory signaling
- Melanocortin pathway (alpha-MSH fragment)
- Intestinal epithelial and immune cells
Reference data
KPV specifications
- Sequence
- Lys-Pro-Val (KPV)
- Classification
- Tripeptide, alpha-MSH C-terminal fragment
- Molecular formula
- C16H30N4O4
- Molecular weight
- ~342.43 g/mol (PubChem CID 125672)
- Appearance
- White lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Molecular formula
- C16H30N4O4
- Molecular weight
- 342.43 g/mol
- Purity
- 99.41%
- CAS number
- 67727-97-3
- PubChem CID
- 125672
Selected research
Published studies on KPV
Peer-reviewed references for further reading. Findings describe in-vitro and animal research; mechanisms and outcomes in humans are not established.
Gastroenterology · 2008
Reported that KPV was taken up into intestinal epithelial and immune cells via the PepT1 transporter and, in that setting, reduced markers of inflammation in cell and mouse colitis models.
Journal of Pharmacology and Experimental Therapeutics · 2003
Observed that the C-terminal alpha-MSH tripeptide KPV exhibited an anti-inflammatory profile distinguishable from that of the core melanocortin peptides in the models examined.
Quality
Independently verified, batch by batch
Tested every batch
Every batch of KPV is independently analyzed by a third-party laboratory before it is released.
Independently verified
Identity and purity are confirmed by an independent third-party laboratory. This batch is verified to 99.41% purity.
Certificate of analysis
Every batch is independently tested with a certificate of analysis. We send a digital COA with your order.
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