- Free worldwide shipping, tracked and insured
- Same day dispatch, customs handled
- Certificate of analysis for every batch
- Chondrogenic differentiation research
- Cartilage and connective-tissue models
- MMP-9 and fibroblast-aging studies
Overview
What is Cartalax?
Cartalax is a synthetic tripeptide, Ala-Glu-Asp (AED), from the Khavinson series of short peptide bioregulators. It is used as a research compound in studies of chondrogenic differentiation, cartilage and connective-tissue markers, and fibroblast aging in cell culture. Supplied for in-vitro and laboratory research use only.
Research applications
Where Cartalax is used in research
Areas of study described in the published literature. Listed for research reference only.
Chondrogenic differentiation
Used in research on cartilage marker expression in human mesenchymal stem cell cultures.
Connective-tissue aging
Studied for MMP-9, proliferation, and apoptosis markers in aging fibroblast models.
Growth-factor signalling
Applied to investigate IGF1 and NF-kB expression in stem-cell aging cultures.
Short-peptide bioregulation
Explored alongside other Khavinson tripeptides to compare gene-expression profiles.
Mechanism in research
How Cartalax is studied
In published research, AED peptide at 200 ng/ml was reported to activate expression of the chondrogenic markers SOX9, aggrecan, type II collagen, and COMP in human mesenchymal stem cells during replicative aging. Separate work in aging skin fibroblast cultures reported inhibition of MMP-9 synthesis, increased Ki-67 and CD98hc, and suppression of caspase-dependent apoptosis, and a stem-cell aging study reported increased IGF1 expression together with stimulated NF-kB expression. These effects are described in cell-culture models; corresponding mechanisms in humans are not established.
Reported targets & pathways
- SOX9, aggrecan, and type II collagen expression
- MMP-9 synthesis
- IGF1 and NF-kB expression
- Caspase-dependent apoptosis
Reference data
Cartalax specifications
- Sequence
- Ala-Glu-Asp (AED)
- Classification
- Synthetic cartilage tripeptide bioregulator
- Appearance
- White lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Molecular formula
- C12H19N3O8
- Molecular weight
- 333.29 g/mol
- Purity
- 99.47%
- PubChem CID
- 87815447
Selected research
Published studies on Cartalax
Peer-reviewed references for further reading. Findings describe in-vitro and animal research; mechanisms and outcomes in humans are not established.
Advances in Gerontology · 2023
Reported that AED peptide at 200 ng/ml activated expression of the chondrogenic markers SOX9, aggrecan, type II collagen, and COMP in human mesenchymal stem cells during replicative aging in vitro.
Bulletin of Experimental Biology and Medicine · 2016
Reported that short peptides including AED inhibited MMP-9 synthesis and raised Ki-67 and CD98hc in aging skin fibroblast cultures, with AED also suppressing caspase-dependent apoptosis.
Molecular Biology Reports · 2020
Reported that AED, KED, and KE at nanomolar concentrations raised IGF1 expression several-fold and stimulated NF-kB expression in two human bone-marrow mesenchymal stem cell aging models.
Quality
Independently verified, batch by batch
Tested every batch
Every batch of Cartalax is independently analyzed by a third-party laboratory before it is released.
Independently verified
Identity and purity are confirmed by an independent third-party laboratory. This batch is verified to 99.47% purity.
Certificate of analysis
Every batch is independently tested with a certificate of analysis. A digital COA is available on request.
Reviews
What researchers say about Cartalax
stessi numeri sulla seconda scatola
Seconda scatola di cartalax, stavolta a Verona. I valori nei saggi sui condrociti sono praticamente uguali alla prima, c'è un pò di variabilità ma niente di strano. È arrivata in otto giorni, la dogana non l'ha nemmeno aperta.
gambled on cartalax
hadnt worked with the AED tripeptide before so i ordered one box to see. COA for the batch came back the same day when i asked. explants havent thrown up anything odd yet. coimbra, seven days
Brosk peptiden kom fram
Beställde cartalax till Västerås, tog fem dagar. Kartongen var lite skrynklig men flaskorna satt fint i skummet och lot numret stämde med certifikatet för batchen. Bac watern fick jag lägga till separat, hade inte fattat det.
customs held it in roissy
The Cartalax is fine, lot matched the certificate and the powder was intact. What cost a star is that the parcel sat at Roissy customs for nine days and nobody could tell me why, Miro support chased it but they cant do much either. Sixteen days door to door to Grenoble, which for a study we had scheduled was annoying.
chondrocyte plates behaved
first time buying cartalax from anyone. primary chondrocyte plates took it without any cytotoxicity at the concentrations we screen at, and the readout moved the direction the older papers describe. leicester in eight days, all ten vials present.
Cartalax FAQ
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