- Free worldwide shipping, tracked and insured
- Same day dispatch, customs handled
- Certificate of analysis for every batch
- Vascular endothelium research
- Endothelin-1 and connexin expression studies
- Sirtuin-1 pathway research
Overview
What is Vesugen?
Vesugen is a synthetic tripeptide, Lys-Glu-Asp (KED), from the Khavinson series of short peptide bioregulators. It is used as a research compound in studies of vascular endothelium, endothelin-1 and sirtuin-1 expression, and endothelial proliferation during aging. Supplied for in-vitro and laboratory research use only.
Mechanism in research
How Vesugen is studied
In published research, KED was reported to normalise endothelin-1 expression raised in atherosclerotic and restenotic endothelial cells and to restore connexin and sirtuin-1 expression in vitro. Separate work reported increased Ki-67 proliferation marker in aged vascular endothelial cultures, with molecular docking suggesting contact with the MKI67 core promoter, and a review described regulation of cell-aging genes (p16, p21) and neuronal differentiation genes (NES, GAP43) in neurogenesis models. These effects are described in cell-culture models; corresponding mechanisms in humans are not established.
Reported targets & pathways
- Endothelin-1 expression
- Connexin and sirtuin-1 (SIRT1) expression
- Ki-67 / MKI67 promoter (proposed)
- p16 and p21 cell-aging genes
Research applications
Where Vesugen is used in research
Areas of study described in the published literature. Listed for research reference only.
Endothelial biology
Used in research on endothelin-1, connexin, and sirtuin-1 expression in vascular endothelial cultures.
Vascular aging
Studied for proliferation-marker expression in aged endothelial tissue and cell models.
Epigenetic regulation
Explored through molecular docking to gene promoters as a proposed mechanism of action.
Neurogenesis models
Applied in studies of cell-aging and neuronal-differentiation gene expression.
Reference data
Vesugen specifications
- Sequence
- Lys-Glu-Asp (KED)
- Classification
- Synthetic vascular tripeptide bioregulator
- Appearance
- White lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Molecular formula
- C15H26N4O8
- Molecular weight
- 390.39 g/mol
- Purity
- 99.61%
- CAS number
- 204271-66-9
- PubChem CID
- 87571363
Selected research
Published studies on Vesugen
Peer-reviewed references for further reading. Findings describe in-vitro and animal research; mechanisms and outcomes in humans are not established.
Advances in Gerontology · 2016
Reported that KED normalised endothelin-1 expression and restored connexin and sirtuin-1 expression in normal, atherosclerotic, and restenotic endothelial cells in vitro.
Advances in Gerontology · 2014
Reported that Vesugen stimulated the proliferation marker Ki-67 in aged vascular endothelial cultures, with molecular docking showing contact with the MKI67 core promoter.
Bulletin of Experimental Biology and Medicine · 2021
Reviewed reports that KED regulates cell-aging genes (p16, p21), neuronal-differentiation genes (NES, GAP43), and Alzheimer-related genes in an in-vitro neurogenesis model.
Quality
Independently verified, batch by batch
Tested every batch
Every batch of Vesugen is independently analyzed by a third-party laboratory before it is released.
Independently verified
Identity and purity are confirmed by an independent third-party laboratory. This batch is verified to 99.61% purity.
Certificate of analysis
Every batch is independently tested with a certificate of analysis. A digital COA is available on request.
Reviews
What researchers say about Vesugen
box looked like it lost a fight
I do the ordering for a small vascular biology group in Sherbrooke and this was our first Vesugen purchase from Miro. The outer box arrived crushed on one corner. Not what you want to see given what ten vials cost. Inside everything was fine, vials seated in foam, none cracked, so the packaging did its job even if the courier did not. The lot matched the batch certificate and the endothelial assays have run without surprises so far. Twelve days including a customs hold in Mississauga. Four stars, mostly for the carton.
gefÀss modell lÀuft damit
zweite bestellung vesugen, diesmal nach bern. im gefĂ€ss modell sehen die werte aus wie bei der ersten charge, beim zoll null probleme. das einzige was mich stört ist das die 10mg flĂ€schchen recht klein wirken fĂŒr den preis, aber gut, das ist bei allen so.
split between two labs
ordered two boxes of vesugen, kept one in poznaĆ and sent the other to our collaborators in wrocĆaw. both lots read the same on hplc so no arguing over which lab got the better one lol. nine days, nothing crushed
KED did what the papers say
ran the KED tripeptide through our endothelial cell model and it behaved the way the khavinson group describes, which i wasnt sure it would given how thin the english language literature is. waterford in five days, first order.
worth it at that price? probably
565 dollars for ten vials made me wince a bit but its 10mg per vial and the batch cert is in order, groningen in a week.
wir haben ewig gesucht
Die kurzen Khavinson Peptide bekommt man in der EU praktisch nirgends, wir haben ewig gesucht. Nach Dresden in sechs Tagen. Charge sauber, und im Endothel Modell verhĂ€lt es sich so wie es in der russischen Literatur beschrieben wird. FĂŒr die erste Charge reicht uns das.
Vesugen FAQ
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