- Free worldwide shipping, tracked and insured
- Same day dispatch, customs handled
- Certificate of analysis for every batch
- T-cell differentiation research
- Immune-senescence and thymic-aging models
- Hematopoietic stem cell studies
Overview
What is Thymalin?
Thymalin is a polypeptide complex isolated from calf thymus, whose characterised active components include the dipeptides Lys-Glu and Glu-Trp. It is used as a research compound in studies of T-cell differentiation, hematopoietic stem cell markers, and immune senescence. Supplied for in-vitro and laboratory research use only.
Mechanism in research
How Thymalin is studied
In published research, Thymalin was reported to reduce CD44 and CD117 expression two- to three-fold and to increase CD28 expression 6.8-fold in human hematopoietic stem cell cultures, interpreted by the authors as stimulation of differentiation toward mature CD28-positive T cells. Its dipeptide components KE and EW were studied by molecular docking to double-stranded DNA and by bioinformatic analysis of gene expression. A 6-8 year observational study of older adults given Thymalin reported lower respiratory-infection incidence. These findings come from cell-culture and observational research; a defined molecular mechanism has not been established.
Reported targets & pathways
- CD28 T-cell co-stimulatory marker
- CD44 and CD117 stem cell markers
- T-lymphocyte differentiation
- KE and EW dipeptide DNA binding (proposed)
Research applications
Where Thymalin is used in research
Areas of study described in the published literature. Listed for research reference only.
T-cell differentiation
Used in research on CD28, CD44, and CD117 markers in human hematopoietic stem cell cultures.
Immune senescence
Studied in models of age-related decline in thymic and T-lymphocyte function.
Thymic peptide biology
Applied to compare the extract with its characterised KE and EW dipeptide components.
Gene-expression bioinformatics
Explored through molecular docking and expression analysis of immune-related genes.
Reference data
Thymalin specifications
- Composition
- Thymic polypeptide complex (calf thymus extract)
- Characterised components
- Lys-Glu (KE) and Glu-Trp (EW) dipeptides
- Appearance
- White to off-white lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Purity
- 99.1%
Selected research
Published studies on Thymalin
Peer-reviewed references for further reading. Findings describe in-vitro and animal research; mechanisms and outcomes in humans are not established.
Bulletin of Experimental Biology and Medicine · 2020
Reported that Thymalin, a polypeptide complex isolated from the thymus, reduced CD44 and CD117 expression and increased CD28 expression 6.8-fold in human hematopoietic stem cell cultures.
International Journal of Molecular Sciences · 2023
Described Thymalin as a polypeptide thymus extract whose active substances KE and EW were studied by molecular docking to double-stranded DNA and by bioinformatic analysis of gene expression.
Neuro Endocrinology Letters · 2003
Reported a 6-8 year observational follow-up of 266 older adults given Thymalin and/or Epithalamin, with lower acute respiratory disease incidence in the treated groups than in controls.
Quality
Independently verified, batch by batch
Tested every batch
Every batch of Thymalin is independently analyzed by a third-party laboratory before it is released.
Independently verified
Identity and purity are confirmed by an independent third-party laboratory. This batch is verified to 99.1% purity.
Certificate of analysis
Every batch is independently tested with a certificate of analysis. A digital COA is available on request.
Reviews
What researchers say about Thymalin
took me months to find this
been trying to get thymalin for our immunosenescence project since spring and every place either had no stock or wanted a purchase order from the university. miro just let me pay and shipped it, brno in 7 days. ran the first vial through the T-cell assay last week and it did what it was supposed to, so yeah, relieved
nothing to add really
Thymalin to Trondheim. Immune panel moved like it should, box was fine, done.
thymalin sorted
Thymalin to Helsinki in six days, dissolved clear, T-cell counts behaved.
asked before it landed
had a question about storage before the thymalin landed and got a proper answer back the same afternoon, not a canned one. box turned up in cork two days later with everything padded in properly.
Spårningen hängde inte med
Thymalin till Västerås för våra T-cellspaneler, andra gången i år vi provar en ny leverantör. Själva varan är det inget fel på, löste sig direkt och värdena ligger där dom ska enligt dom äldre studierna. Men spårnings sidan stod på behandlas i fem dagar och sen låg paketet plötsligt i brevlådan, så vi hade ingen aning om när det skulle komma. Fyra stjärnor för det, annars fem.
Where the old papers put it
We have been running thymalin in an immune-senescence model for about two years and sourcing it has always been the weak point. First lot from Miro. The T-cell panel moved in the direction the older Russian papers describe, which is what we wanted to see before ordering more than one box. Reconstitution was uneventful. The COA for the batch, which they sent when we asked, sat close to our own read, closer than I expected honestly. Montpellier in eight days with a weekend in the middle.
Thymalin FAQ
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