- Free worldwide shipping, tracked and insured
- Same day dispatch, customs handled
- Certificate of analysis for every batch
- Melanocortin MC3R/MC4R receptor research
- Central nervous system pathway studies
- Alpha-MSH analogue pharmacology
Overview
What is PT-141?
PT-141 (bremelanotide) is a cyclic heptapeptide analogue of alpha-MSH that acts as an agonist at melanocortin receptors MC3R and MC4R. It is used as a research compound in studies of melanocortin receptor pharmacology and central nervous system signalling pathways. Supplied for in-vitro and laboratory research use only.
Mechanism in research
How PT-141 is studied
In published research, PT-141 was characterised as a melanocortin agonist with high affinity for MC4R and activity at MC3R. Preclinical work in female rat models reported that its behavioural effects were mediated centrally, with site-specific brain administration and microdialysis pointing to hypothalamic melanocortin circuits rather than peripheral vascular effects. Early human pharmacokinetic studies of intranasal and subcutaneous administration reported a half-life of roughly two hours, and later phase 2 and phase 3 programmes evaluated a subcutaneous formulation. These findings describe the published literature; the compound is supplied here strictly as a research reference standard.
Reported targets & pathways
- Melanocortin receptor 4 (MC4R)
- Melanocortin receptor 3 (MC3R)
- Hypothalamic melanocortin circuits
- Alpha-MSH signalling
Research applications
Where PT-141 is used in research
Areas of study described in the published literature. Listed for research reference only.
Melanocortin receptor pharmacology
Used in binding and signalling assays characterising MC3R and MC4R agonism.
Central nervous system pathways
Studied in rodent models of hypothalamic melanocortin signalling.
Alpha-MSH analogue comparison
Explored alongside MT-2 and other analogues to compare receptor selectivity.
Pharmacokinetic research
Applied in published studies of intranasal and subcutaneous administration routes.
Reference data
PT-141 specifications
- Sequence
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
- Classification
- Cyclic heptapeptide alpha-MSH analogue, MC3R/MC4R agonist
- Appearance
- White lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Molecular formula
- C50H68N14O10
- Molecular weight
- 1025.2 g/mol
- Purity
- 99.44%
- CAS number
- 189691-06-3
- PubChem CID
- 9941379
Selected research
Published studies on PT-141
Peer-reviewed references for further reading. Findings describe in-vitro and animal research; mechanisms and outcomes in humans are not established.
Journal of Sexual Medicine · 2007
Reviewed preclinical work in female rat models reporting that bremelanotide acted through central melanocortin pathways, using site-specific brain administration and microdialysis to localise the effect.
International Journal of Impotence Research · 2004
Reported pharmacokinetic and safety data for intranasal PT-141 in healthy males and patients, describing the compound as a cyclic heptapeptide melanocortin analogue with a half-life of roughly two hours.
Obstetrics and Gynecology · 2019
Reported two 24-week randomised, placebo-controlled phase 3 trials (RECONNECT) of a subcutaneous bremelanotide formulation in premenopausal women, with nausea, flushing and headache the most frequently reported adverse events.
Quality
Independently verified, batch by batch
Tested every batch
Every batch of PT-141 is independently analyzed by a third-party laboratory before it is released.
Independently verified
Identity and purity are confirmed by an independent third-party laboratory. This batch is verified to 99.44% purity.
Certificate of analysis
Every batch is independently tested with a certificate of analysis. A digital COA is available on request.
Reviews
What researchers say about PT-141
fair price for ten
Granada here, first time buying from them. The local distributor wanted more for five vials than Miro charges for the box of ten so that decision made itself. Cakes all intact, and the one vial I have put through the melanocortin panel so far looked normal. Lets see how the other nine go.
mc4r curve unchanged
reordered for the melanocortin binding work and the mc4r curve overlays the april lot, strasbourg again, nothing new to say
out for delivery, allegedly
We are a four-person neuro group in Athlone and this was our first PT-141 from Miro, bought for a melanocortin receptor panel, mostly MC4R with some MC3R on the side. The compound is fine. Dissolved on the first attempt and the binding numbers on the first two plates sit close to what the older pharmacology papers report. My complaint is the delivery. The courier had it marked out for delivery for the better part of a week and a half, nothing moved, and support could only see the same screen I could, which is a special kind of annoying. The peptide gets five, the courier gets three, so four it is.
foam insert earned its keep
box came through customs opened and retaped, which happens, but the foam insert kept all ten vials seated and the lyo cakes were intact. first vial went into the melanocortin panel on monday and did what the last supplier's did. maastricht btw
mc4r panel wieder komplett
hatten pt-141 vorher immer über einen us händler bezogen und jedes mal ewig auf den zoll gewartet, jetzt kommt es innerhalb der eu und nichts bleibt hängen. im hypothalamusschnitt verhält es sich genauso wie das alte material, die mc4r bindung liegt im erwarteten bereich. gut das es das jetzt hier gibt
MC4R plates ran clean
Needed something for MC4R binding plates and wasnt sure the 10mg was the right format for a neuro group as small as ours, so I emailed before paying. Straight answer by the next morning, no upsell. Southampton, box was fine. First plate came out where we expected, which is more than the last lot from elsewhere managed.
PT-141 FAQ
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