- Free worldwide shipping, tracked and insured
- Same day dispatch, customs handled
- Certificate of analysis for every batch
- Dual incretin receptor agonist research (GIP + GLP-1)
- Glucose-dependent insulin signaling pathway studies
- Body-composition and adiposity research
Overview
What is GLP-2 (TZ)?
GLP-2 (TZ) is a synthetic dual incretin receptor agonist that activates both the GIP and GLP-1 receptors from a single peptide. It is used as a research compound in studies of incretin signaling, glucose regulation, and body composition. Supplied for in-vitro and laboratory research use only.
Mechanism in research
How GLP-2 (TZ) is studied
In published research GLP-2 (TZ) was characterized as a fatty-acid-modified peptide that binds and activates the GIP and GLP-1 receptors, two incretin pathways that converge on glucose-dependent insulin signaling. Discovery-stage pharmacology reported dual-agonist activity at both receptors, and subsequent controlled trials observed changes in body weight over the periods studied. Corresponding long-term mechanisms and outcomes in humans remain under investigation.
Reported targets & pathways
- GIP receptor
- GLP-1 receptor
- Incretin signaling axis
- Glucose-dependent insulin secretion
Reference data
GLP-2 (TZ) specifications
- Classification
- Synthetic dual GIP/GLP-1 receptor agonist peptide
- Development code
- LY3298176
- Appearance
- White lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Molecular formula
- C225H348N48O68
- Molecular weight
- 4813.53 g/mol
- Purity
- 99.27%
- CAS number
- 2023788-19-2
- PubChem CID
- 166567236
Research applications
Where GLP-2 (TZ) is used in research
Areas of study described in the published literature. Listed for research reference only.
Incretin receptor pharmacology
Used to study parallel signaling at the GIP and GLP-1 receptors from a single dual-agonist peptide.
Glucose metabolism
Applied in research on glucose-dependent insulin secretion and metabolic regulation.
Body composition
Investigated in animal and clinical research models for effects on body weight and adiposity.
Comparative agonist studies
Explored alongside single-incretin agonists to compare dual- versus single-pathway activity.
Selected research
Published studies on GLP-2 (TZ)
Peer-reviewed references for further reading. Findings describe in-vitro and animal research; mechanisms and outcomes in humans are not established.
Molecular Metabolism · 2018
Reported the discovery and pharmacological characterization of LY3298176, a fatty-acid-modified peptide engineered as a dual agonist at the GIP and GLP-1 receptors.
New England Journal of Medicine · 2022
In the SURMOUNT-1 randomized trial, the once-weekly dual GIP/GLP-1 agonist was observed to produce substantial mean body-weight reductions over 72 weeks relative to placebo across the doses studied.
Comparison
GLP-2 (TZ) vs single-incretin agonists in research
| GLP-2 (TZ) | GLP-1 agonist | GIP agonist | |
|---|---|---|---|
| Receptor target | GIP + GLP-1 | GLP-1 receptor | GIP receptor |
| Class | Dual incretin agonist | Single incretin agonist | Single incretin agonist |
| Research focus | Combined incretin signaling | GLP-1 pathway | GIP pathway |
| Pathways engaged | Two | One | One |
Quality
Independently verified, batch by batch
Tested every batch
Every batch of GLP-2 (TZ) is independently analyzed by a third-party laboratory before it is released.
Independently verified
Identity and purity are confirmed by an independent third-party laboratory. This batch is verified to 99.27% purity.
Certificate of analysis
Every batch is independently tested with a certificate of analysis. A digital COA is available on request.
Reviews
What researchers say about GLP-2 (TZ)
hplc checks out on the tirz
ran the tirz through our own hplc when it landed in manchester and the numbers sat right on the published coa. reconstituted clear. ordering the bigger format next.
same day reply
had a question about the format before ordering and support came back same day. shipment to valencia was quick and packed well.
am konstantesten von den dreien
dritter anbieter, den wir für den dualagonisten testen, und der hier ist bisher am konstantesten. die werte im modell lagen da wo die literatur sagt. ein stern runter, weil die lieferung nach wien deutlich länger gebraucht hat als angegeben
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