- Free worldwide shipping, tracked and insured
- Same day dispatch, customs handled
- Certificate of analysis for every batch
- Telomerase and telomere-length research
- Pineal gland and melatonin-rhythm studies
- Cellular senescence and longevity models
Overview
What is Epithalon?
Epithalon (Epitalon) is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, derived from the amino-acid composition of the pineal extract Epithalamin. It is used as a research compound in studies of telomerase activity, pineal melatonin rhythms, and cellular-aging pathways. Supplied for in-vitro and laboratory research use only.
Mechanism in research
How Epithalon is studied
In published research, Epithalon was reported to induce expression of the telomerase catalytic subunit, telomerase enzymatic activity, and telomere elongation in telomerase-negative human fetal fibroblast cultures. Separate work in aged rhesus monkeys reported restored night-time melatonin output from the pineal gland, and a stem-cell study reported increased expression of neurogenic differentiation markers, with molecular modelling suggesting binding to histone H1 sites as a possible epigenetic mechanism. These pathways are investigated in cell and animal models; the corresponding mechanisms in humans are not established.
Reported targets & pathways
- Telomerase catalytic subunit (TERT) expression
- Pineal melatonin synthesis
- Histone H1 binding (proposed epigenetic mechanism)
- Neurogenic differentiation markers (Nestin, GAP43)
Research applications
Where Epithalon is used in research
Areas of study described in the published literature. Listed for research reference only.
Telomerase biology
Used in research on telomerase activation and telomere length in human somatic cell cultures.
Pineal and circadian research
Studied for effects on pineal melatonin rhythms in aged primate models.
Cellular aging
Applied in lifespan, biomarker-of-aging, and oxidative-stress studies in rodent models.
Epigenetic regulation
Explored for histone-binding and neurogenic gene-expression effects in stem-cell cultures.
Reference data
Epithalon specifications
- Sequence
- Ala-Glu-Asp-Gly (AEDG)
- Classification
- Synthetic pineal tetrapeptide bioregulator
- Appearance
- White lyophilized powder
- Solubility
- Soluble in bacteriostatic water
- Molecular formula
- C14H22N4O9
- Molecular weight
- 390.35 g/mol
- Purity
- 99.52%
- CAS number
- 307297-39-8
- PubChem CID
- 219042
Selected research
Published studies on Epithalon
Peer-reviewed references for further reading. Findings describe in-vitro and animal research; mechanisms and outcomes in humans are not established.
Bulletin of Experimental Biology and Medicine · 2003
Reported that adding Epithalon to telomerase-negative human fetal fibroblast cultures induced expression of the telomerase catalytic subunit, telomerase enzymatic activity, and telomere elongation.
Biogerontology · 2003
Reported that Epitalon in female SHR mice increased the lifespan of the last 10% of survivors, reduced bone-marrow chromosome aberrations, and lowered leukemia incidence, without changing mean lifespan.
Molecules · 2020
Reported that AEDG raised neurogenic differentiation markers in human gingival mesenchymal stem cells and, by molecular modelling, preferentially bound histone H1 sites, proposed as an epigenetic mechanism.
Quality
Independently verified, batch by batch
Tested every batch
Every batch of Epithalon is independently analyzed by a third-party laboratory before it is released.
Independently verified
Identity and purity are confirmed by an independent third-party laboratory. This batch is verified to 99.52% purity.
Certificate of analysis
Every batch is independently tested with a certificate of analysis. A digital COA is available on request.
Reviews
What researchers say about Epithalon
took the scenic route through customs
Ordered after the podcast episode this summer made the rounds in our lab group chat, since we run a circadian model and wanted to see the pineal data for ourselves. The peptide itself is fine, clean lyo and the telomerase readout sits where the published cell work says it should. The four stars are for the transit. US customs sat on the parcel in Chicago for eleven days with no movement, then it showed up in Madison the next morning. Not Miro's fault exactly but plan for it if you are stateside.
second box
reordered the 10mg before the first ten vials ran out, aalborg, nothing changed between lots
in stock when nobody else had it
Everyone wanted epitalon after the july vote and half the usual places were sold out or quoting september. Miro had the 10mg. Valencia in eight days and the lot reads clean in our senescence markers. Genuinely relieved, we had a grant deadline hanging on those cells.
byter inte tillbaka
Vi har kört epitalon från en annan leverantör i två år och testade Miro mest för att priset på 50mg var svårt att säga nej till. Telomeras aktiviteten i cellinjerna ligger på samma nivå som med det gamla, om nåt lite jämnare mellan flaskorna. Skickat till Umeå på fem dagar. Kollegan var skeptisk först men han har tystnat
pineal panel behaved
first epitalon lot, went in clear and the pineal cell panel behaved, so nothing to add from lyon
telomerase readout held
We picked up the 10mg for a telomerase activity assay we run in fibroblast lines, mostly to see whether a new supplier would shift our baseline. It did not. Activity came up in the treated wells at roughly the level the older papers describe and the untreated controls stayed flat, so nothing odd in the vial. Went into solution without a fuss. Leeds, delivery took about a week which is what I expected from abroad. The ten vials went quicker than I budgeted for, which is on me.
Epithalon FAQ
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